Journal article
Dissecting the Syndrome of Schizophrenia: Progress toward Clinically Useful Biomarkers
Brian Dean
SCHIZOPHRENIA RESEARCH AND TREATMENT | HINDAWI LTD | Published : 2011
DOI: 10.1155/2011/614730
Abstract
The search for clinically useful biomarkers has been one of the holy grails of schizophrenia research. This paper will outline the evolving notion of biomarkers and then outline outcomes from a variety of biomarkers discovery strategies. In particular, the impact of high-throughput screening technologies on biomarker discovery will be highlighted and how new or improved technologies may allow the discovery of either diagnostic biomarkers for schizophrenia or biomarkers that will be useful in determining appropriate treatments for people with the disorder. History tells those involved in biomarker research that the discovery and validation of useful biomarkers is a long process and current pr..
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Awarded by NHMRC
Funding Acknowledgements
The author would like to acknowledge Geoffrey Pavey, Simone Boer, and Alison Digney for assisting in running and analysing 2D gels to visualise proteins in Brodmann's area 46 from subjects with schizophrenia, bipolar disorder, and controls. The work described in the manuscript was supported in part by NHMRC Grant no. APP1002240, NHMRC Grant no. 192339, R01 MH069696-01 and grants-in aid from the Rebecca L. Cooper Medical Research Foundation. The study was supported by Operational Infrastructure Support (OIS) from the Victorian State Government.